Last year’s semi-finalist Lorenzo Musetti, the No.7 seed, lost 6-2, 4-6, 7-5, 6-1 to Georgia’s Nikoloz Basilashvili, who is ranked 126 in the world and hadn’t won a Grand Slam main draw match in three years before his big upset on Tuesday.
Musetti was unable to play any warmup events on grass this season due to a left leg injury he picked up at Roland-Garros that sidelined him between both majors.
Denmark’s Holger Rune blamed a knee injury for his 4-6, 4-6, 7-5, 6-3, 6-4 loss to Chile’s Nicolas Jarry.
“If I play normal, I'm beating him nine out of 10 times, with all respect for Nicolas Jarry. Obviously today didn't make it a lot easier with my knee, but yeah, it was not great,” said the No.8 seed.
Meanwhile, ninth-seeded Daniil Medvedev, who was a semi-finalist at Wimbledon the last two years was stunned by France’s Benjamin Bonzi 7-6(2), 3-6, 7-6(3), 6-2.
Medvedev admitted he may have underestimated his opponent heading into the match.
“I’m surprised by his level. I know that he can play well. But I would be surprised if you find a match of him playing like this any other match this year. I'm surprised he did today. But it can happen. That's when sensations happen,” said the former US Open champion.
Seeded men who lost in the Wimbledon first round:
No.3 Zverev, No.7 Musetti, No.8 Rune, No.9 Medvedev, No.16 Cerundolo, No.18 Humbert, No.20 Popyrin, No.24 Tsitsipas, No.27 Shapovalov, No.28 Bublik, No.30 Michelsen, No.31 Griekspoor, No.32 Berrettini